You need to give more detail like what your protein is, which force field
you are using etc ... Do you know its melting temperature? Be specific as
possible.
Hai Nguyen
On Thu, Jun 7, 2012 at 11:58 PM, Soumya Lipsa Rath
<soumyalipsabt.gmail.com>wrote:
> Dear Amber Users,
>
> I am trying to run Replica exchange MD simulation implicitly. During the
> equilibration step and at higher temperatures, the structure of my protein
> becomes distorted. I have given the chirality restraints on the protein
> backbone. I wanted to know whether structural distortions at higher
> temperatures in normal or do I need to modify/add some parameters?
>
> Thanks,
>
> Soumya
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Received on Sat Jun 09 2012 - 22:00:02 PDT
