Thank you for your help and immediately reply.
Jacky
David A Case <david.case.rutgers.edu>于2017年9月1日 周五下午8:42写道：
> On Fri, Sep 01, 2017, jacky zhao wrote:
> >
> > Therefore, I am wondering the role of ACE and NME capping protein in the
> > protein simulation.
>
> At the risk of telling you what you already know:
>
> Chemists who synthesize peptides often add capping groups, for various
> reasons.
> The ACE and NME/NHE caps are provided in the Amber libraries so that
> simulations can be made on such artificial systems.
>
> Cells (at least in the vast majority of cases) don't cap anything; if there
> is something other than an ordinary (charged) amino acid at the N- or
> C-terminus, it would be considered a post-translational modification (and
> would
> probably have a different chemistry than ACE or NME.)
>
> Generally, to simulate an "ordinary" protein, one would not use capping
> groups.
> (There are, of course, exceptions to every rule, and others on the list
> might
> want to chime in.) In standard usage, ACE and NME capping groups would
> only be called for when dealing with synthetic peptides.
>
> ....dac
>
>
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--
Lei Zhao, Ph.D.
International Joint Cancer Institute of the Second Military Medical
University
National Engineering Research Center for Antibody Medicine
New Library Building 11th floor,800 Xiang Yin Road
Shanghai 200433
P.R.China
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Received on Fri Sep 01 2017 - 09:00:03 PDT
