[AMBER] Stability calculations from MMGB/PBSA

From: Rajeswari A. <rajeswari.biotech.gmail.com>
Date: Wed, 11 Nov 2015 14:24:14 +0530

Dear all,
I did protein and its mutants simulations. I wanted to calculate the
ralative stability of mutant protein with respect to wild type protein.

For that can i use MMGB/PBSA analysis specifying the protein as complex
(although it is a single entity)?

Using MMGBSA, the resultant difference between mutant and wildtype is ~300
Kcal/mol. Is the difference acceptable? Please suggest.

Thanks in advance

Rajeswari A,
PhD Research Scholar,
Computational Biophysics Lab,
Department of Biotechnology,
Indian Institute of Technology Madras,
Chennai 600 036, Tamil Nadu, India.
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Received on Wed Nov 11 2015 - 01:00:03 PST
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