On Sun, Sep 13, 2009, Ashish Runthala wrote:
> So now explain me, if we consider the system neutralized, why the
> charged side chains of amino acids exist in nature.
Don't confuse overall charge neutrality (which is always present, at any pH or
other conditions) with local neutrality at a given site (which will depend on
pH, for example.)
> If i need to change pH of the protein system. What should i do to
> attain it. I need to equilibrate my protein at pH 8.25
This has been discussed many time on the list; a couple of ideas were just
posted a few days ago:
http://structbio.vanderbilt.edu/archives/amber-archive/2009/4474.php
...dac
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Received on Mon Sep 14 2009 - 13:45:44 PDT
