Hello Sally,
If you are interested to perform NMR refinement on symmetric dimers, you
may be interested to try the software ARIA:
aria.pasteur.fr, which is dedicated to this problem.
Hope it helps,
Therese Malliavin
Unite de Bioinformatique Structurale
Institut Pasteur, Paris
France
Sally Pias wrote:
> Hello,
>
> I am wondering whether there is a way to carry out NMR refinement on a
> dimeric system where ambiguities need to be defined across the two
> monomeric units. For example, residue A has a distance restraint
> involving residue Q, but it is unknown whether the restraint should be
> applied between residues A and Q on the same protomer or between
> residue A on one protomer and residue Q' on the other protomer.
> Group coordinate averaging for such an ambiguity could lead to a
> structural distortion, assuming that residues Q and Q' are fairly
> distant from one another.
>
> Any insights or suggestions?
>
> Thank you,
>
> Sally Pias
>
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Received on Fri Feb 13 2009 - 01:07:50 PST
