Hello,
I am wondering whether there is a way to carry out NMR refinement on a
dimeric system where ambiguities need to be defined across the two
monomeric units. For example, residue A has a distance restraint
involving residue Q, but it is unknown whether the restraint should be
applied between residues A and Q on the same protomer or between
residue A on one protomer and residue Q' on the other protomer.
Group coordinate averaging for such an ambiguity could lead to a
structural distortion, assuming that residues Q and Q' are fairly
distant from one another.
Any insights or suggestions?
Thank you,
Sally Pias
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Received on Wed Feb 11 2009 - 01:25:58 PST
