Dear Dr. Sponer,
Thank you very much for you prompt response.
So can I conclude that poly(rC) doesn't exist in the double stranded
form?
> There is i-RNA too,
> The RNA i-motif
> Snoussi K et al
> JOURNAL OF MOLECULAR BIOLOGY 309 139-153 2001
I haven't heard of this work earlier. And therefore thought that
only DNA can form i-motif (this was the opinion of my more experienced
colleagues).
I've tryed to model tetrameric i-motif RNA structure (modifying
190d.pdb). And in this case the initial stucture remained intact
during the minimization. As for the 100ps md simulation in the implicit
solvent, the planarity of bases was coserved, though one of the narrow
grooves became significantly wider compared to the initial structure.
********************************************
Kateryna Miroshnychenko
post-graduate student
Department of Biological Physics,
Institute of Radiophysics and Electronics,
National Academy of Sciences of Ukraine,
12, Proskura st., Kharkiv, 61085, Ukraine
E-mail:kateryna_mirosh.ire.kharkov.ua
********************************************
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Received on Sun Feb 19 2006 - 06:10:11 PST
