Computational investigation of protein-ligand free energies
A post-doctoral position is available, starting October 1st 2001, to
investigate protein-ligand association using statistical mechanics
simulations on massively parallel architectures. The project focuses
on applying free energy methodology to rank the affinities of a series
of pharmacologically active ligands to a protein of interest. Results
will be confronted to micro-calorimetry and BiaCore experiments
performed by collaborating research groups. Funding of this project is
provided by a leading pharmaceutical company.
Applicants should have a strong background in statistical mechanics,
specifically in free energy methodologies, and be familiar with
molecular simulations of biological systems and performance programming
on massively parallel machines.
For further information, please, contact Dr. Chris Chipot:
Phone: (33) 3-83-91-25-96
Fax: (33) 3-83-91-25-30
E-mail: chipot_at_lctn.uhp-nancy.fr
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Chris Chipot, Ph.D.
Equipe de chimie et biochimie théoriques Phone: (33) 3-83-91-25-96
Unite mixte de recherche CNRS/UHP No 7565 Fax: (33) 3-83-91-25-30
Université Henri Poincaré - Nancy I
B.P. 239
54506 Vandoeuvre-lès-Nancy Cedex E-mail: chipot_at_lctn.uhp-nancy.fr
http://www.lctn.uhp-nancy.fr/Chercheurs/Chris.Chipot
And they, who assert that everything is right, do
not express themselves correctly; they should say
that everything is best.
Voltaire
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Received on Mon Jul 23 2001 - 16:32:19 PDT
