Hi Everyone,
I'm currently working with a heterodimer protein complex in which one protein is phosphorylated and this interaction has been shown in vitro to be required for dimer formation.
Using MM/PBSA, would it be possible to perform an energy deconvolution to determine the energy contribution of the phosphoserine and the two salt bridges it is forming?
I am familiar with protein-ligand calculations, but in this case it is protein-protein.
Any advice would be greatly appreciated.
Best,
Parker
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Received on Thu Jun 18 2015 - 07:00:03 PDT
