Re: [AMBER] Forcefield for RNA

From: Jason Swails <>
Date: Fri, 24 Oct 2014 09:19:43 -0400

On Fri, Oct 24, 2014 at 8:46 AM, Asfa Ali <> wrote:

> Sir,
> When I did the simulations with:
> tleap -s -f leaprc.ff99bsc0
> loadoff RNA_CI.lib
> source leaprc.gaff
> ...
> I did not notice any perturbation in the RNA structure. So is it necessary
> to repeat the calculations using ff14SB?

​Well if any of the people that have responded to this thread already were
to review your paper, I think they made it pretty clear that they would
reject work that uses ff99bsc0 for RNA rather than some of the much better,
newer force fields.

All the best,

Jason M. Swails
Rutgers University
Postdoctoral Researcher
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Received on Fri Oct 24 2014 - 06:30:02 PDT
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