2010/12/19 Catein Catherine <askamber23.hotmail.com>
>
> Did any one read any publication reported that the potential of mean force
> for a drug dissociation from its receptor could be as high as 100 kcal/mol?
>
>
The most tight non-covalent complexes reported are avidin/streptavidin and
barnase/barstar (and some other rnase with rnase inhibitor). Kd of these
complexes lie below femtomol/liter order, which is equivalent to free energy
slightly below -20 kcal/mol. Free energy near 100 kcal/mol corresponds to
the Kd ~10E-73 M. How to measure this huge energy value? Maybe by
calorimetry technique?
--
Sincerely,
Dmitry Mukha
Institute of Bioorganic Chemistry, NAS, Minsk, Belarus
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Received on Sun Dec 19 2010 - 11:00:09 PST
