> I would like to parametrize charges for DNA bases that contain some
> chemical modifications. The modifications are pretty simple and
> contain atom types that are already defined within the AMBER force
> field.
>
> In order to parametrize charges, however, I would like to follow the
> method used for the rest of the DNA bases. That is, I would like to
> fit the RESP charges to the bases while restraining the charges on the
> sugar group to certain values. That way, this base should be
> compatible with the rest of the bases in the AMBER force field. Is
> there software that will aid in this process?
