RE: AMBER: enzyme kinetics in silico

From: Xu, Yong <>
Date: Tue, 3 Apr 2007 15:26:45 -0400






From: [] On Behalf Of Suxin Zheng
Sent: 200714 12:55
Subject: Re: AMBER: enzyme kinetics in silico


I am interested in it. What's the theory basis and has it been published? How you realize it.


On Jan 4, 2007, at 9:24 AM, Sean Rathlef wrote:

Greetings simulation enthusiasts:


Our group is nearing completion of a beta platform which will enable users to model enzyme kinetics constants (Km, Vmax, Ki, etc) on a computer as opposed to in the laboratory. It is the first such process of its kind, and can be used to model elasticity coefficients for metabolic control analysis (MCA). In knowing that access to kinetic data can be a limiting factor in the generation of models, I thought I would post this memo FYI.


At present, we are seeking to identify prospective users for this technology. The methods will be included in an intuitive interface, whereby users will be able to model their enzymes and generate their kinetic data using a predefined set of software methods. Again, this is the first such platform of its kind, and we are hoping that the beta will be available for evaluation in a few weeks time.


If any of you are interested in hearing more, or would like to be included on our list of future evaluators, please send me an email with your contact information to <> .


Thanks in advance, and we look forward to hearing from you soon.


Sean Rathlef

Managing Director

Syncitium Inc




Suxin Zheng

Research Associate, Varani Group

Box 351700

Department of Chemistry, University of Washington

Seattle, WA, 98195-1700




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Received on Wed Apr 04 2007 - 06:07:49 PDT
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