From: Monica <>
Date: Sat 16 Nov 2002 13:10:15 +0500 (GMT)

Dear Sir,
I have 2 problems:

1) While doing DNA-drug minimization using NMR restraints in vacuum in
presence of conterions ,the sodium ions are forming triangulated structure
with Phosphate of DNA. First I minimize conterions but in that step only
it forms triangulated structure with Phosphate of DNA. I have tried
minimization with slow heating too (I am doing it only at 300 K)

2) Secondly I don't want to put group input on DNA while doing
minimization but removal of group input leads planer rings of DNA -drug
to be distorted.

What shall I do?
Thank you for ant help.

Deptt Biotech
IITR, Roorkee
Received on Sat Nov 16 2002 - 00:10:15 PST
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