What is the current consensus on the timescale of deoxyribose ring
repuckering in double-helical DNA in solution? I've come across some
references that state approximately 10 ns, while others suggest several
north-south transitions per ns. I'm just wondering how many transitions in
an MD simulation would be closest to nature, and how long to conduct an MD
run to approach a statistically relevant ensemble for studying repuckering
in a particular sequence.
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/|||X|||\ /|||X|||\ / Richard J. (Jake) Isaacs \ /|||X|||\ /|||X|||\
X|||/ \|||X|||/ \|||X Department of Molecular X|||/ \|||X|||/ \|||X
`-' `-' `-' `-' \ & Cellular Biochemistry / `-' `-' `-' `-'
.-. .-. .-. .-. / University of Kentucky \ .-. .-. .-. .-.
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\|||X|||/ \|||X|||/ \ Lexington, KY 40536-0084 / \|||X|||/ \|||X|||/
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Received on Tue Jan 22 2002 - 08:43:40 PST
