Hello,
I'm a beginner in bionmr.
I'm trying to solve DNA-duplex structure using MD with NOESY volumes as
restraints.
When I try to minimize the structure it looks like the molecule doesn't
feel any restraints: I tried to increase restraints weights, to use random
volumes values and no volumes restraints at all - resulting structures are
nearly the same (<0.5 RMSD).
Could it be connected with a wrong value of "oscale" parameter? I failed
to find any information about its determination. How could I estimate it?
Thanks
Eugene
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Received on Mon Jul 06 2015 - 04:30:02 PDT
