From: Ramin Ekhteiari <ramin_ekh.yahoo.com>
Date: Tue, 5 May 2015 17:59:41 +0000 (UTC)

Hi Dears,
I try to use MM_PBSA.py script to estimate delta free energy value between a ligand and a GPCR (membrane protein). but the problem is that, GPCRs are considered as membrane proteins and they share  large hydrophobic domains which are embedded into the membrane bilayer, so this method how can work by applying dielectric constant for overall atoms of protein. Can we use this method for GPCRs as well as other proteins.

I appreciate for any advice.   

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Received on Tue May 05 2015 - 11:00:04 PDT
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