Dear amber users,
I used mm-pbsa to calculate the binding free energy of a protein-DNA complex,
Is the PBTOT given as the out put of this is the relative binding free energy?
If I want to calculate the absolute binding free energy ( in order to compare it with the experimental value) should I subtract T∆ S (calculated using normal mode analysis) from PBTOT ?
Thank you,
_______________________________________________
AMBER mailing list
AMBER.ambermd.org
http://lists.ambermd.org/mailman/listinfo/amber
Received on Wed Jun 04 2014 - 02:30:03 PDT
