[AMBER] concerted effect of the backbone movement

From: <abhay.strubi.ox.ac.uk>
Date: Fri, 3 Jun 2011 16:11:03 +0100 (BST)

Dear All,

We are very new to MD simulations. I are interested in stabilizing a two protein complex. I have successfully optimized the MM_PBSA approach for our needs.

I am now interested in looking the effect of the concerted movement, that may occur further away from the two protein interface. We feel that this movement might contribute to the instability of the complex. Is there are way in Amber to look at such kind of effects.



Abhay Kotecha
DPhil Student
Division of Structural Biology
Henry Wellcome Building for Genomic Medicine,
Oxford, OX3 7BN, UK
Ph: +44 (0)1865 287541
Mobile: +44 (0)7702794123

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Received on Fri Jun 03 2011 - 08:30:02 PDT
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