Dear Sir/Madam,
I am trying to calculate the interaction energy between domain 1 and 2 of a protein. Since domain 1 and 2 are connected, i cannot define a separated prmtop file for each domain. I guess I cannot use MMPBSA/GBSA methods to get this interaction energy. Are there any other methods I can use to estimate the binding energy between domains?
Best regards,
Cat with thanks.
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Received on Mon Jul 19 2010 - 01:00:03 PDT
