On Sun, Aug 16, 2009, Catein Catherine wrote:
>
> I am trying to study the DNA bending due to DNA modifications. I wonder
> if it is typically feasible to do the calculations with AMBER. Are
> there any precaution should I take into account?
There have been lots of studies of DNA bending with un-modified DNA. Study
these and see if they seem feasible to carry out with modifications. Think
about how accurate and precise a result you would need to obtain to really see
the effect of the modification. And make sure that you have a good chance of
learning something new -- your goal should not be to just reproduce some value
that has already been measured.
...dac
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Received on Wed Aug 19 2009 - 22:44:42 PDT
