Dear Amber Brothers
I am working with some noval DNA
binding Drug analogues to see their interactions with
ds and Triplex DNA. Some interesting things I want to
see with these are:
*Interactions Involve (Covalent and Non-covalent
between leads and DNA)
*Stability issue for the DNA(specificaly Triplex DNA)
*Place of Binding(Minor Vs Major)
Now my question is: If the Simulation is the right
choice then how I proceed? Is Docking necessry before
simulation?
Note: Since Drug leads are novel in my case, they do't
have the crystal structure entry in RCSB-PDB.
Please help
Many Thanks
------------------------------------------------
Puneet Kacker
Project Associate
Medicinal Chemistry Research Laboratory
Dr. B.R. Ambedkar Centre for Biomedical Research
University of Delhi-North Campus
Delhi
INDIA
____________________________________________________________________________________
No need to miss a message. Get email on-the-go
with Yahoo! Mail for Mobile. Get started.
http://mobile.yahoo.com/mail
-----------------------------------------------------------------------
The AMBER Mail Reflector
To post, send mail to amber.scripps.edu
To unsubscribe, send "unsubscribe amber" to majordomo.scripps.edu
Received on Sun Jan 28 2007 - 06:07:13 PST
