> I have a system which falls apart when implicit solvent is used. The
> system is composed of non-watson-crick bases; but it is experimentally
> shown that has a stable structure (and most probably a helical structure).
How did you equilibrate? Have you successfully equilibrated w-c bases?
Nucleic acids in general are sensitive in this regard.
Bill
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Received on Sun Oct 22 2006 - 06:07:33 PDT
